2014年1月16日 星期四

[陽明大一普通生物]神經系統 part1



1.      神經細胞:neuron
Dendrites:樹突;axon:軸突;axon hillock:軸丘
Soma細胞本體;myelin sheath髓鞘;node of Ravier:蘭氏節


神經膠細胞Glial cell:主要有三種
(1)           OligodendrocyteCNS
Schwann cellPNS
構成myelin sheath→傳速較快→node of Ranvier(蘭氏節)

(2)           astrocyte:星狀細胞→提供養分,支持作用
(3)           microgliaremove debris
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神經傳導的細部過程:
1.      兩種膜電位:
(1)   graded potential:刺激越大,反應越大;只能傳到一段區域,後逐漸消失
(2)   action potential:反應不因刺激大而更大(改變頻率),能夠不斷的傳下去
all or none:全有全無律(超過threshold)
2.      action potential sequencedepolarizationrepolarizationhyperpolarizationNa-K Pumpresting potential
(1)   depolarization:超過threshold(-50mv)voltage gated ion channel open(Na+)
大量鈉離子湧入→depolarization1ms內進入inactivation(不反應期)
必須恢復resting potential→反應才能繼續進行
(refractory period:給予頻率刺激的上限,並阻止電訊號往反方向傳遞)
(2)   repolarization:超過threshold(40mv)voltage gated ion channel open(K+)
鉀離子離開細胞→過量的鉀離子離開→形成hyperpolarization→由鈉鉀pump恢復resting potential
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1. 突觸:synapse
(1)   電性突觸:利用gap junction
(2)   化學突觸:利用neurotransmitter
Step
動作電位→鈣離子通道打開→促進神經傳導物質的分泌→synaptic cleftpostsynaptic cell→產生EPSP (興奮性)or IPSP(抑制性)

2. 5neurotransmitter
(1)   Acetylcholine:乙醯膽鹼
Released at the synapsesneuromuscular junction(運動終板)
對於骨骼肌,大腦:excitatory
對於心肌:inhibitory
蛇毒→可以抑制acetylcholine receptor→肌肉無法收縮
(2)   Biogenic aminecompound that formed from amino acid
包括:dopamine, epinephrine, norepinephrine
與情緒相關→psychoactive
(3)   amino acid
glutamateexcitatory neurotransmitter
GABAinhibitory neurotransmitter →打開氯離子通道
(4)   neuropeptide
short chain of amino acid
often calledneuromodulator→改變突觸後細胞的狀態(ex.增加受體)
oxytocin(催產素)trust/bond/social recognition
opiate peptide:腦內啡→help deal with stress
(5)   gaseous neurotransmitter
NOrelaxing smooth muscleerection

3. Postsynaptic receptor
1.      ionotropic
ligand-gated ion channel
when bind to neurotransmitter→→ion channel open or closeEPSP
2.      metabotropic
G-protein coupled receptor
When bind to neurotransmittersecond messengerchange in postsynaptic cell

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